Product Details
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89-86-1 Name |
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Name |
2,4-Dihydroxybenzoic acid |
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Synonym |
2,4-Dihydrox;Sodium aminosalicylate Impurity 3;2,4-Dihydroxybenzoesure;p-hydroxysalicylicacid;Resorcylic acid, beta;-Resorcylicacid;2,4-DIHYDROXYBENZOIC ACID / BETA-RESORCYLIC ACID;SS-RESORCYLIC ACID |
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89-86-1 Chemical & Physical Properties |
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Melting point |
208-211 °C (dec.)(lit.) |
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Boiling point |
414.8±15.0 °C at 760 mmHg |
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Density |
1.6±0.1 g/cm3 |
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Molecular Formula |
C7H6O4 |
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Molecular Weight |
154.120 |
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Flash Point |
218.8±16.9 °C |
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PSA |
77.76000 |
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LogP |
1.60 |
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Exact Mass |
154.026611 |
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Vapour Pressure |
0.0±1.0 mmHg at 25°C |
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Index of Refraction |
1.671 |
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Water Solubility |
8 g/L (20 ºC) |
2,4-Dihydroxybenzoic acid, also known as protocatechuic acid, is a chemical compound that has been studied in various scholarly articles for its potential applications. One of its primary uses is as a natural antioxidant and anti-inflammatory agent. It has been found to have a protective effect against oxidative stress and inflammation, making it a potential therapeutic agent for various diseases, such as cardiovascular disease, diabetes, and cancer. Additionally, 2,4-Dihydroxybenzoic acid has been investigated for its potential antimicrobial and antiviral properties. It has also been studied as a potential agent for the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. However, further research is needed to fully explore and understand the extent of its applications and potential benefits in these areas.
InChI:InChI=1/C7H6O4/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,8-9H,(H,10,11)/p-1
The aqueous Kolbe-Schmitt synthesis using resorcinol to yield 2,4-dihydroxy benzoic acid was performed in a microreactor rig. This small-scale plant was equipped initially with one capillary reactor and one microstructured cooler only. Later, two upgraded versions were constructed, having in addition a microstructured cooler and a microstructured mixer, respectively. The chemical protocol was significantly varied as compared to standard laboratory operation as described in the literature. Higher temperatures (up to 220°C) and pressures (up to 74 bar) were employed in a facile manner, termed high-p,T processing. In this way, the reaction time could be shortened by orders of magnitude, from about 2 hours to less than one minute, in some cases to some seconds. This resulted in a remarkable increase of the space-time yield by a factor of 440 at best. Productivity was in the L/h range and yielded at best 111 g/h product, corresponding to 4 t/a. Scale-out solutions are indicated. Drawbacks of the microreactor operation were also identified such as high sensitivity to fouling and delicate regulation of the system pressure, leading to partly unstable plant operation. Possibly even a considerable part of the product was rearranged to 2,6-dihydroxybenzoic acid and then thermally decomposed under the harsh reaction conditions. Solutions to overcome or at least diminish these restrictions are envisaged, and in the hope that this may be achieved, a process innovation and business perspective for the high-p,T microreactor processing is depicted.
Herein, we present a study on the catalytic evaluation of biocompatible chitosan-stabilized gold nanoparticles (CH-AuNPs) on the oxidation of morin as a model reaction. Biocompatible CH-AuNPs have been characterized through several analytical methods such as TEM, UV–vis, DLS and zeta potential analyses. CH-AuNPs have a small size (10 ± 0.4 nm) with a narrow size distribution and high positive surface charge (+40.1 mV). CH-AuNPs has been demonstrated to be highly active nanocatalysts for the oxidation of morin with the assistance of H2O2 as an oxidant compared with control experiments. The oxidation reaction follows a pseudo-first-order reaction. The kinetic studies show that apparent rate constant (kapp) is positively correlated with the concentrations of CH-AuNPs and H2O2, while it is negatively correlated with morin concentration. Furthermore, the reusability tests have been performed and the results demonstrate the long-term stability and reusability of CH-AuNPs without any loss of catalytic activity. Cytotoxicity studies exhibit that CH-AuNPs have low toxicity and they are biocompatible with HeLa and MCF-7 cells.
A fully automated on-line system for monitoring the TiO2-based photocatalytic degradation of dimethyl phthalate (DMP) and diethyl phthalate (DEP) using sequential injection analysis (SIA) coupled to liquid chromatography (LC) with UV detection was proposed. The effects of the type of catalyst (sol-gel, Degussa P25 and Hombikat), the amount of catalyst (0.5, 1.0 and 1.5 g L-1), and the solution pH (4, 7 and 10) were evaluated through a three-level fractional factorial design (FFD) to verify the influence of the factors on the response variable (degradation efficiency, %). As a result of FFD evaluation, the main factor that influences the process is the type of catalyst. Degradation percentages close to 100% under UV-vis radiation were reached using the two commercial TiO2 materials, which present mixed phases (anatase/rutile), Degussa P25 (82%/18%) and Hombikat (76%/24%). 60% degradation was obtained using the laboratory-made pure anatase crystalline TiO2 phase. The pH and amount of catalyst showed minimum significant effect on the degradation efficiencies of DMP and DEP. Greater degradation efficiency was achieved using Degussa P25 at pH 10 with 1.5 g L-1 catalyst dosage. Under these conditions, complete degradation and 92% mineralization were achieved after 300 min of reaction. Additionally, a drastic decrease in the concentration of BOD5 and COD was observed, which results in significant enhancement of their biodegradability obtaining a BOD5/COD index of 0.66 after the photocatalytic treatment. The main intermediate products found were dimethyl 4-hydroxyphthalate, 4-hydroxy-diethyl phthalate, phthalic acid and phthalic anhydride indicating that the photocatalytic degradation pathway involved the hydrolysis reaction of the aliphatic chain and hydroxylation of the aromatic ring, obtaining products with lower toxicity than the initial molecules.
monoethyl phthalate
2-(ethoxycarbonyl)-5-hydroxybenzoic acid
phthalic anhydride
4-hydroxysalicylic acid
4-hydroxyphthalic acid
benzene-1,2-dicarboxylic acid
| Conditions | Yield |
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With sodium hydroxide; In water; pH=10; Reagent/catalyst; pH-value; Catalytic behavior; UV-irradiation;
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Monomethyl phthalate
5-hydroxy-2-(methoxycarbonyl) benzoic acid
phthalic anhydride
4-hydroxysalicylic acid
4-hydroxyphthalic acid
benzene-1,2-dicarboxylic acid
| Conditions | Yield |
|---|---|
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With sodium hydroxide; In water; pH=10; Reagent/catalyst; pH-value; Catalytic behavior; UV-irradiation;
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7-hydroxy-2H-chromen-2-one
7-hydroxycoumarin-4-carboxylic acid
4,6-dihydroxyisophthalic acid
2,2,2-trichloro-1-(2,4-dihydroxy-phenyl)-ethanone
4-methoxymethylsalicylate
2,4-dihydroxy-benzoic acid-[3-(2-methyl-piperidino)-propylester]; hydrochloride
methyl 2,4-dihydroxybenzoate
methyl 2-hydroxy-4-methoxy-3-methylbenzoate
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