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Product Details
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236117-38-7 Name |
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Name |
2-iodo-1-p-tolyl-propan-1-one |
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Synonym |
2-IODO-1-P-TOLYL- PROPAN-1-ONE;1-Propanone, 2-iodo-1-(4-methylphenyl)-;2-Iodo-1-p-tolylpropan-1-one 2-Iodo-1-(4-methylphenyl)-1-propanone 2-Iodo-1-(4-methylphenyl)-propan-1-one 2-Iodo-1-(p-methylphenyl)-1-propanone 2-Iodo-1-(p-methylphenyl)-propan-1-one 2-Iodo-4'-methylpropiophenone α-Iodo-4'-methylpropiophenone 2-йод;OEM α-Iodo-4-methylpropiophenone;2-Iodo-1-(4-methylphenyl)-1-propanone;alpha-Iodo-4'-methylpropiophenone;2-io2-iodo-1-p-tolyl-propan-1-onedo-1-p-tolyl-propan-1-one;2-iodo-1-p-tolyl-propan-1-one Basic information |
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236117-38-7 Chemical & Physical Properties |
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Boiling point |
310.5±25.0 °C(Predicted) |
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Density |
1.584±0.06 g/cm3(Predicted) |
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Molecular Formula |
C10H11IO |
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Molecular Weight |
274.1 |
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236117-38-7 Uses |
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Used as a pharmaceutical intermediate. |
2-iodo-1-p-tolyl-propan-1-one is a chemical compound that has various applications in organic synthesis. One of its most common uses is as a reagent for the preparation of substituted ketones and aldehydes. It can react with various nucleophiles such as Grignard reagents, organolithium compounds, and enolates to form a wide range of products. Additionally, it can be used as a starting material for the synthesis of complex natural products and pharmaceuticals. The unique properties of 2-iodo-1-p-tolyl-propan-1-one make it a valuable tool for chemists in the development of new compounds and materials.
A one-pot alkylation–halogenation of ketosulfoxonium ylides in the presence of alkyl halides is described. The method furnishes several gem-difunctionalized haloketones (an alkyl and F, Cl, Br, or I) in good yields. Replacing alkyl halides with a mixture of electrophilic halogen species and various halide anions led to gem-dihalogenated ketones containing a combination of the same or two different halogens. Kinetic isotopic effects as well as reaction kinetic experiments give insight to the mechanism of these reactions.
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Direct conversion of carbonyl compounds into α-iodocarbonyl compounds has been successfully achieved under solvent-free microwave irradiation conditions using N-iodosuccinimide and p-toluenesulfonic acid.
α-Iodoketones are prepared in high yields from the initial reaction of various ketones with HNIB in CH3CN and subsequent treatment of potassium iodide or samarium(II) iodide.
4'-methylpropiophenone
2-iodo-1-(p-tolyl)propan-1-one
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With N-iodo-succinimide; toluene-4-sulfonic acid; Microwave irradiation;
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90% |
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With [hydroxy(tosyloxy)iodo]benzene; iodine; 1-butyl-3-methylimidazolium Tetrafluoroborate; at 60 ℃; Ionic liquid;
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84% |
4-Nitro-benzenesulfonic acid 1-methyl-2-oxo-2-p-tolyl-ethyl ester
2-iodo-1-(p-tolyl)propan-1-one
| Conditions | Yield |
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With 18-crown-6 ether; potassium iodide; In acetonitrile; at 20 ℃; for 1h;
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2-bromo-4'-methylpropiophenone
4'-methylpropiophenone
methyl iodide
4-methyl-benzoyl chloride
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