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  • Product NameClotrimazole
  • Molecular FormulaC22H17ClN2
  • Purity99%
  • AppearanceCrystalline

Product Details

Quick Details

  • CasNo: 23593-75-1
  • Molecular Formula: C22H17ClN2
  • Appearance: Crystalline
  • Purity: 99%

Export API Clotrimazole 23593-75-1 In Stock

23593-75-1 Name






23593-75-1 Chemical & Physical Properties

Melting point 


Boiling point

482.3±40.0 °C at 760 mmHg


1.1±0.1 g/cm3

Molecular Formula


Molecular Weight


Flash Point

245.5±27.3 °C





Exact Mass


Vapour Pressure

0.0±1.2 mmHg at 25°C

Index of Refraction


Storage condition

Store at RT.

Water Solubility

Soluble in chloroform, DMSO, DMF and alcohols


23593-75-1 Description

Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor.Target: Antifungal; CYPClotrimazole (brand name Canesten or Lotrimin) is an antifungal medication commonly used in the treatment of fungal infections (of both humans and other animals) such as vaginal yeast infections, oral thrush, and ringworm. It is also used to treat athlete's foot and jock itch.It is commonly available as an over-the-counter substance in various dosage forms, such as a cream, and also (especially in the case of ear infection) as a combination medicine. It is also available as a troche or throat lozenge (prescription only). For ear infection, it is often applied in liquid form, as ear drops.The antimycotic drug clotrimazole inhibits the function of the gastric H,K-ATPase in a manner similar to that observed for the Na,K-ATPase. Because of the high hydrophobicity of the compound, the interaction between clotrimazole and the ion pump occurs at the membrane domain in the apolar core of the membrane. The enzymatic activity was inhibited with a half-saturating concentration of 5.2 microM. Various partial reactions of the pump cycle were analyzed with the electrochromic styryl dye RH421 that has been widely used to study the transport mechanism of P-type ATPases.


23593-75-1 Uses

  1. Clotrimazole is an antifungal agent.
  2. An antifungal compound and CYP inhibitor.
  3. Clotrimazole (Lotrimin, Mycelex, etc.) is a synthetic imidazole agent. It acts by altering cell membrane permeability. It inhibits the growth of most dermatophyte species, yeast and Malassezia furfur.




23593-75-1 Relevant articles



Fluorinated Alcohol-Promoted Reaction of Chlorohydrocarbons with Diverse Nucleophiles for the Synthesis of Triarylmethanes and Tetraarylmethanes


Yu, Liping,Li, Shuai-Shuai,Li, Weina,Yu, Shitao,Liu, Qing,Xiao, Jian

, p. 15277 - 15283 (2019/01/04)

This article reports an efficient synthesis of triarylmethanes and tetraarylmethanes from chlorohydrocarbons with miscellaneous nucleophiles in fluorinated alcohols, featuring metal-free, wide substrate scope, excellent functional group tolerance, and mild reaction conditions.

Synthesis method of clotrimazole


Paragraph 0020; 0021; 0022; 0023; 0024; 0025; 0026-0076, (2018/03/28)

The invention discloses a synthesis method of clotrimazole, and belongs to the technical field of chemical synthesis. According to the method, 2-chlorotrityl chloride and imidazole are taken as raw materials, hexafluoroisopropanol is taken as a solvent, and reaction is performed in an alkali environment.