Product Details
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6108-05-0 Name |
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Name |
Linocaine hydrochloride |
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Synonym |
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrate hydrochloride;N1-(2,6-dimethylphenyl)-N2,N2-diethylglycinamide hydrochloride hydrate;Linocaine hydrochloride(lidocaine HCL);LIDOCAINE HCL BP (INJECTABLE GRADE);Lignocaine monohydrate hydrochloride, Xylocaine monohydrate hydrochloride, 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide monohydrate hydrochloride;2-Dimethylamino-N-(2,6-dimethylphenyl)acetamide hydrochloride;Lidocaine Hydrochloride BP98 USP24;Lignocaine hydrochloride monohydrate |
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6108-05-0 Chemical & Physical Properties |
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Melting point |
68.5ºC |
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Boiling point |
350.8ºC at 760 mmHg |
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Molecular Formula |
C14H25ClN2O2 |
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Molecular Weight |
288.814 |
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Flash Point |
166ºC |
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PSA |
41.57000 |
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LogP |
3.39440 |
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Exact Mass |
288.160461 |
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Water Solubility |
H2O: soluble |
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6108-05-0 Description |
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Lidocaine hydrochloride hydrate (Lignocaine hydrochloride hydrate) inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride hydrate decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride hydrate is an amide derivative and has potential for the research of ventricular arrhythmia. |
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6108-05-0 Uses |
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Linocaine hydrochloride is a fast voltage-gated sodium channel blocker that used in Local anesthesia and heart rhythm disorders. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine. |
The synthesis and characterization, using NMR (1H and 13C), infrared spectroscopy, and X-ray crystallography, of the ethene and carbon monoxide copper(i) complexes of hydridotris(3,5-diphenylpyrazol-1-yl)borate ([Tp(Ph)2]-) and the two new ligands hydridotris(3,5-bis(1-naphthyl)pyrazol-1-yl)borate ([Tp((1Nt))2]-) and hydridotris(3,5-bis-(2-naphthyl)pyrazol-1-yl)borate ([Tp((2Nt))2]-) are described. X-ray crystal structures are presented of [Cu(Tp(Ph)2)(C2H4)] and [Cu(Tp((2Nt))2)(C2H4)].
Ion exchange of layered alkali titanates (Na2Ti3O7, K2Ti4O9, and Cs2Ti5O11) with several alkali metal halides surprisingly proceeded in the solid-state at room temperature. The reaction was governed by thermodynamic parameters and was completed within a shorter time when the titanates with a smaller particle size were employed. On the other hand, the required time for the ion exchange was shorter in the cases of Cs2Ti5O11 than those of K2Ti4O9 irrespective of the particle size of the titanates, suggesting faster diffusion of the interlayer cation in the titanate with lower layer charge density.
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