15687-27-1

Quick Details

• CasNo： 15687-27-1
• Molecular Formula： C₁₃H₁₈O₂
• Appearance： Colourless, crystalline solid
• Purity： 99%

Buy USP Ibuprofen 15687-27-1 Factory Price

Relevant articles

Synthesis, pharmacological activity and hydrolytic behavior of glyceride prodrugs of ibuprofen

Khan,Akhter, Mymoona

, p. 371 - 376 (2005)

For reducing the gastrointestinal toxicity associated with ibuprofen its carboxylic group was condensed with the hydroxyl group of 1,2,3-trihydroxy propane 1,3-dipalmitate/stearate to give the ester prodrugs 3a and 3b. The release of ibuprofen from these prodrugs has been studied at pH 3, 4, 5 and 7.4 by HPLC using methanol and 0.05% phosphoric acid (80%) (70:30) as mobile phase. The prodrugs showed insignificant hydrolysis at pH 5 compared to pH 7.4 indicating that the prodrugs do not break in stomach but release ibuprofen at pH 7.4 in adequate amounts. In vivo hydrolysis studies in rats, the peak plasma concentration of ibuprofen was attained in 1.5:h in case of ibuprofen and in 2:h in prodrugs treated animals.

The continuous-flow synthesis of ibuprofen

Bogdan, Andrew R.,Poe, Sarah L.,Kubis, Daniel C.,Broadwater, Steven J.,McQuade, D. Tyler

, p. 8547 - 8550 (2009)

Let relief flow forth I A three-step, continuous-flow synthesis of ibuprofen was accomplished using a simplified microreactor. By designing a synthesis in which excess reagents and byproducts are compatible with downstream reactions, no intermediate purification or isolation steps are required.