Product Details
We offer High Purity Cyclopropanecarboxylic Acid. Cyclopropanecarboxylic acid is a monocarboxylic acid and a member of cyclopropanes. It is a conjugate acid of a cyclopropanecarboxylate.
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1759-53-1 Name |
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Name |
Cyclopropanecarboxylic acid |
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Synonym |
Carboxycyclopropane;Cyclopropionic acid;CYCLOPROPYLMETHANOIC ACID;CYCLOPROPYL CARBOXYLIC ACID;CYCLOPROPANE CARBOYLIC ACID;CYCLOPROPANECARBOXYLIC ACID;CPC-ACID;RARECHEM AL BO 0005 |
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1759-53-1 Chemical & Physical Properties |
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Melting point |
17-19 ºC |
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Boiling point |
182-184 ºC |
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Density |
1.085 |
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Molecular Formula |
C4H6O2 |
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Molecular Weight |
86.089 |
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Flash Point |
71 ºC |
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PSA |
37.30000 |
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LogP |
0.08 |
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Exact Mass |
86.036781 |
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Vapour Pressure |
0.4±0.7 mmHg at 25°C |
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Index of Refraction |
1.437-1.439 |
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Storage condition |
0-6°C |
Cyclopropanecarboxylic acid is a chemical compound that has been studied in various scholarly articles for its potential applications. One of its primary uses is as a building block in organic synthesis. It can be used as a starting material for the synthesis of various compounds, including pharmaceuticals, agrochemicals, and fine chemicals.
InChI:InChI=1/C4H6O2/c5-4(6)3-1-2-3/h3H,1-2H2,(H,5,6)/p-1
Comparison of the stability of valacyclovir 13 with the cyclopropane analogue 14 shows that at 40 degrees C and pH 6 the half-life of 14 is >300 h while the value for 13 is 69.7 h. CBS-QB3 calculations on isodesmic reactions for transfer of groups from an alkane to an ester show that a cyclopropyl group provides hyperconjugative stabilization.
The use of methyl 4-bromobutanoate or the lithium salt of 4-bromobutanoic acid in these reactions did not produce the required products whereas alkylation using trimethyl ortho-4-bromobutanoate (15) gave methyl 7-hydroxyhept-5-ynoate (5) or the corresponding THP ether (4) in good yield after orthoester hydrolysis.Procedures are also described for the transformation of alcohol (5) and THP (4) into methyl 7-bromohept-5-ynoate (1).Alcohol (5) can also be converted into methyl (Z)-7-bromohept-5-enoate (2) using literature procedures.
The atomic substitution process proceeds smoothly through the photochemical reactivity of the formed hydrogen-bonding adduct between thioacids and DMSO. A DMSO-involved proton-coupled electron transfer (PCET) and the simultaneous generation of thiyl and hydroxyl radicals are proposed to be key steps for realizing the transformation.
The results of this study implicate a polar two-electron process via an oxygen-stabilised carbenium species, rather than a single-electron process involving radical intermediates. The structure–reactivity relationships revealed here will assist synthetic chemists in deploying this type of methodology in the syntheses of α-fluoroketones.
The practicality of this reaction has been demonstrated by conducting several 50 mmol-scale reactions using pure oxygen or an air-flow of ~30 mL/min.
An object of the present invention is to provide and develop novel agricultural and horticultural insecticides in view of the still immense damage caused by insect pests etc. and the emergence of insect pests resistant to existing insecticides in crop production in the fields of agriculture, horticulture and the like.
cyclopropanecarboxylic acid 2-(2-acetyl-4-butyrylamino-phenoxy)-1-(isopropylamino-methyl)-ethyl ester
Acebutolol
cyclopropanecarboxylic acid
| Conditions | Yield |
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With water; at 37 ℃; pH=1 - 12; Further Variations:; Reagents; Kinetics;
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cyclopropanecarboxylic acid chloride
2-fluorobenzyl chloride
1-cyclopropyl-2-(2-fluorophenyl)ethanone
2-Fluorotoluene
2-fluorobenzyl alcohol
cyclopropanecarboxylic acid
| Conditions | Yield |
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2-fluorobenzyl chloride; With iodine; magnesium; In diethyl ether; for 2h; Heating / reflux;
cyclopropanecarboxylic acid chloride; In tetrahydrofuran; diethyl ether; at -70 - 20 ℃;
With water; ammonium chloride; Product distribution / selectivity;
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naphthalene
cyclopropane-1,1-dicarboxylic acid
4-Chlorobutyronitrile
Cyclopropyl methyl ketone
N-phenylcyclopropanecarboxamide
2-cyclopropyl-1H-benzo[d]imidazole
Cyclopropancarbonsaeure-isopropylester
methyl cyclopropylcarboxylate
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